منابع مشابه
Vesicle trafficking and membrane remodelling in cytokinesis.
All cells complete cell division by the process of cytokinesis. At the end of mitosis, eukaryotic cells accurately mark the site of division between the replicated genetic material and assemble a contractile ring comprised of myosin II, actin filaments and other proteins, which is attached to the plasma membrane. The myosin-actin interaction drives constriction of the contractile ring, forming ...
متن کاملBiophysics of α-synuclein induced membrane remodelling.
α-Synuclein is an intrinsically disordered protein whose aggregation is a hallmark of Parkinson's disease. In neurons, α-synuclein is thought to play important roles in mediating both endo- and exocytosis of synaptic vesicles through interactions with either the lipid bilayer or other proteins. Upon membrane binding, the N-terminus of α-synuclein forms a helical structure and inserts into the h...
متن کاملImaging Membrane-protein Diffusion in Living Bacteria
I would like to gratefully acknowledge the following members of the reading committee for reviewing my thesis: programme Nanoscopy: from sharp imaging toward imaging of molecular interaction. The cover shows images of E. coli bacteria expressing fluorescently labeled CstA trans-membrane protein. Dedicated to my parents and girlfriend It is not the strongest of the species that survive, nor the ...
متن کاملRevolutionizing membrane protein overexpression in bacteria
The bacterium Escherichia coli is the most widely used expression host for overexpression trials of membrane proteins. Usually, different strains, culture conditions and expression regimes are screened for to identify the optimal overexpression strategy. However, yields are often not satisfactory, especially for eukaryotic membrane proteins. This has initiated a revolution of membrane protein o...
متن کاملPhysical principles of membrane remodelling during cell mechanoadaptation
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological ...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2016
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2016.05.010